The Metabolic Milieu of Metastases
نویسندگان
چکیده
To colonize the liver, colon cancer metastases must overcome hypoxia and other metabolic stress. Loo et al. now show that metastatic cells achieve this by decreasing miR-483 and miR-551a expression, which derepresses creatine kinase expression and allows energy to be captured from extracellular ATP through generation and import of phosphocreatine.
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ورودعنوان ژورنال:
- Cell
دوره 160 شماره
صفحات -
تاریخ انتشار 2015